tailieunhanh - Báo cáo y học: " Fat tissue and adiponectin: new players in critical care"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Fat tissue and adiponectin: new players in critical care? | Available online http content 13 4 174 Commentary Fat tissue and adiponectin new players in critical care Maciej Owecki Department of Endocrinology Metabolism and Internal Medicine University of Medical Sciences in Poznan ul. Przybyszewskiego 49 60-355 Poznan Poland Corresponding author Maciej Owecki mowecki@ Published 5 August 2009 This article is online at http content 13 4 174 2009 BioMed Central Ltd Critical Care 2009 13 174 doi cc7974 See related research by Venkatesh et al. http content 13 4 R105 Abstract Historically adipose tissue was thought to be a passive tissue that stores energy and protects the body from temperature and injury. In contrast to this concept it is now evident that adipose tissue is an active endocrine organ secreting many kinds of adipocytokines including adiponectin. Presumably adipose tissue and its products may have some impact on numerous pathways of response to trauma sepsis and stress. The discussion on a plausible role of adiponectin in critical illness has been raised by the fact of finding hypoadiponectinemia in critically ill patients. The nature of this phenomenon however remains to be elucidated and noteworthy clinical studies should prompt further efforts in basic research to explain the mechanisms beyond the clinical observation of low adiponectin levels in humans with severe illness. In the current issue of Critical Care Venkatesh and colleagues present a novel study on adiponectin in critical illness 1 . This article along with the concept of adipose tissue and adipocytokines being involved in the mechanisms of critical illness requires some commentary. Historically adipose tissue was thought to be an inert tissue that stores energy and protects the body from temperature and injury. In contrast to this concept it is now evident that adipose tissue is an active endocrine organ secreting many kinds of adipocytokines - such as adiponectin leptin IL-6 and TNFa - that may .