tailieunhanh - Báo cáo y học: "The Importance of the Discourse on the Method"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The Importance of the Discourse on the Method. | Vitiello Child and Adolescent Psychiatry and Mental Health 2010 4 2 http content 4 1 2 CHILD ADOLESCENT PSYCHIATRY MENTAL HEALTH EDITORIAL Open Access The Importance of the Discourse on the Method Benedetto Vitiello Central to the research enterprise is the application of scientific methods appropriate to achieving the investigational aims. In the case of controlled clinical trials assay sensitivity is achieved through careful selection of study sample design and assessment instruments. Treatments and controls must be precisely defined and quantified. Concomitant interventions need to be specified and delimited. The actual implementation of the protocol requires procedures for ensuring fidelity consistency and reproducibility. Typically a clinical trial protocol is the result of contributions from experts in clinical care experimental methodology bioethics statistics and data management. Appreciating the research methodology of a study is critical for understanding the value and the limitations of the results. The quality of methods is especially important in the case of so called negative trials as are often called studies that though designed to reject a null hypothesis of equivalence do not find significant differences between treatments. Distinguishing a truly negative trial . a study indicating that no difference between treatments actually exists from a failed trial . a study that lacks assay sensitivity and is unable to detect a difference even if it exists depends primarily on the strength of the research methodology of the trial. While considerable effort usually goes into preparing the methods for a controlled clinical trial only a fraction of this work is actually mentioned in the publication of the results. There are several reasons for this situation. First space limitations prevent a detailed description of the methodology and a critical discussion of the theoretical and practical reasons for the choices that were made vis-à-vis .