tailieunhanh - Báo cáo hóa học: " Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Novel Strategy to Fabricate PLA/Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro | Li et al. Nanoscale Res Lett 2011 6 29 http content 6 1 29 o Nanoscale Research Letters a SpringerOpen Journal NANO EXPRESS Open Access Novel Strategy to Fabricate PLA Au Nanocomposites as an Efficient Drug Carrier for Human Leukemia Cells in Vitro Jingyuan Li 1 Chen Chen1 Xuemei Wang1 Zhongze Gu1 Baoan Chen2 Abstract Poly lactic acid PLA polymer has the promising applications in the biomedical field because of its biodegradability and safe elimination. In this study we have explored the bio-application of new nanocomposites composed with PLA nanofibers and Au nanoparticles as the potential drug carrier for an efficient drug delivery in target cancer cells. The results demonstrated that the anticancer drug daunorubicin could be efficiently self-assembled on the surface of PLA Au nanocomposites and the synergistic enhancement of PLA Au nanocomposites conjugated with daunorubicin into drug-sensitive K562 and drug-resistant leukemia K562 AO2 cells could be obviously observed by MTT assay and confocal fluorescence microscopy studies. These observations suggest that the new nanocomposites could readily induce daunorubicin to accumulate and uptake in target leukemia cells and increase the drug s cytotoxicity. Especially the PLA Au nanocomposites could significantly facilitate the cellular drug absorbtion of daunorubicin into drug-resistant K562 AO2 cells and efficiently inhibit the cancer cell proliferation. This raised the possibility to utilize the PLA Au nanocomposites as a new effective additive agent to inhibit the drug resistance and thus as a novel strategy to sensitively track the respective cancer cells. Introduction As one of the difficult treated diseases cancer threats the life of many patients. To reduce the morbidity and mortality of cancer early diagnosis and cancer systemic therapies are of paramount importance. The cure efficiency of cancer chemotherapy depends not only on the anticancer drug itself but also on how the drug .

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