tailieunhanh - báo cáo khoa học: " The nature of fibrous dysplasia"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: The nature of fibrous dysplasia | Head Face Medicine BioMed Central Open Access Review The nature of fibrous dysplasia Liviu Feller 1 Neil H Wood1 Razia AG Khammissa1 Johan Lemmer1 and Erich J Raubenheimer2 Address Department of Periodontology and Oral Medicine School of Dentistry Faculty of Health Sciences University of Limpopo Medunsa Campus Pretoria South Africa and 2Department of Oral Pathology School of Dentistry Faculty of Health Sciences University of Limpopo Medunsa Campus Pretoria South Africa Email Liviu Feller - lfeller@ Neil H Wood - oralmed@ Razia AG Khammissa - rkhammissa@ Johan Lemmer - jbowman@ Erich J Raubenheimer - Corresponding author Published 9 November 2009 Received 8 May 2009 LJ. I 0 r M-J --. . j-MAiioi n IZAVCAA Accepted 9 November 2009 Head Face Medicine 2009 5 22 doi 1746-160X-5-22 This article is available from http content 5 1 22 2009 Feller et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Fibrous dysplasia has been regarded as a developmental skeletal disorder characterized by replacement of normal bone with benign cellular fibrous connective tissue. It has now become evident that fibrous dysplasia is a genetic disease caused by somatic activating mutation of the Gsa subunit of G protein-coupled receptor resulting in upregulation of cAMP. This leads to defects in differentiation of osteoblasts with subsequent production of abnormal bone in an abundant fibrous stroma. In addition there is an increased production of IL-6 by mutated stromal fibrous dysplastic cells that induce osteoclastic bone resorption. Introduction Fibrous dysplasia FD is a .