tailieunhanh - báo cáo khoa học: " Biological activity of a genetically modified BMP-2 variant with inhibitory activity"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Biological activity of a genetically modified BMP-2 variant with inhibitory activity | Head Face Medicine BioMed Central Research Biological activity of a genetically modified BMP-2 variant with inhibitory activity Uwe Klammert 1 Joachim Nickel2 Kristian Wurzler1 Christoph Klingelhoffer1 Walter Sebald2 Alexander C Kubler1 and Tobias Reuther1 Open Access Address Department of Cranio-Maxillo-Facial Surgery University of Wurzburg Pleicherwall 2 97070 Wurzburg Germany and 2Department of Physiological Chemistry II Biocenter University of Wuerzburg Am Hubland 97074 Wurzburg Germany Email Uwe Klammert - uweklammert@ Joachim Nickel - Nickel@ Kristian Wurzler - Wuerzler_K@ Christoph Klingelhoffer - Klingelhoe_C@ Walter Sebald - Sebald@ Alexander C Kubler - Kuebler_A@ Tobias Reuther - Reuther_T@ Corresponding author Published 2 February 2009 Head Face Medicine 2009 5 6 doi l746-l60X-5-6 Received 17 April 2008 Accepted 2 February 2009 This article is available from http content 5 l 6 2009 Klammert et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Alterations of the binding epitopes of bone morphogenetic protein-2 BMP-2 lead to a modified interaction with the ectodomains of BMP receptors. In the present study the biological effect of a BMP-2 double mutant with antagonistic activity was evaluated in vivo. Methods Equine-derived collagenous carriers were loaded with recombinant human BMP-2 rhBMP-2 in a well-known dose to provide an osteoinductive stimulus. The study was performed in a split animal design carriers only coupled with rhBMP-2 control were implanted into prepared cavities of lower limb muscle of rats .

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