tailieunhanh - báo cáo khoa học: " Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw | Cella et al. Head Face Medicine 2011 7 16 http content 7 1 16 HEAD FACE MEDICINE CASE REPORT Open Access Autologous bone marrow stem cell intralesional transplantation repairing bisphosphonate related osteonecrosis of the jaw 11 2 2 3 4 Luigi Cella Aldo Oppici Mariacristina Arbasi Mauro Moretto Massimo Piepoli Daniele Vallisa Adriano Zangrandi5 Camilla Di Nunzio 4 and Luigi Cavanna4 Abstract Purpose Bisphosphonate - related osteonecrosis of the JAW BRONJ is a well known side effect of bisphosphonate therapies in oncologic and non oncologic patients. Since to date no definitive consensus has been reached on the treatment of BRONJ novel strategies for the prevention risk reduction and treatment need to be developed. We report a 75 year old woman with stage 3 BRONJ secondary to alendronate and pamidronate treatment of osteoporosis. The patient was unresponsive to recommended treatment of the disease and her BRONJ was worsening. Since bone marrow stem cells are know as being multipotent and exhibit the potential for differentiation into different cells tissue lineages including cartilage bone and other tissue we performed autologous bone marrow stem cell transplantation into the BRONJ lesion of the patient. Methods Under local anesthesia a volume of 75 ml of bone marrow were harvested from the posterior superior iliac crest by aspiration into heparinized siringes. The cell suspension was concentrated using Ficoll - Hypaque centrifugation procedures in a final volume of 6 ml. Before the injection of stem cells into the osteonecrosis the patient underwent surgical toilet local anesthesia was done and spongostan was applied as a carrier of stem cells suspension in the bone cavity then 4 ml of stem cells suspension and 1 ml of patient s activated platelet-rich plasma were injected in the lesion of BRONJ. Results A week later the residual spongostan was removed and two weeks later resolution of symptoms was obtained. Then the lesion improved with .