tailieunhanh - báo cáo khoa học: " Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graf"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graf | Puricelli et al. Head Face Medicine 2010 6 10 http content 6 1 10 HEAD FACE MEDICINE RESEARCH Open Access Characterization of bone repair in rat femur after treatment with calcium phosphate cement and autogenous bone graft Edela Puricelli 1 Adriana Corsetti2 Deise Ponzoni3 Gustavo L Martins2 Mauro G Leite4 and Luis A Santos5 Abstract Background In this study the biocompatibility stability and osteotransductivity of a new cement based on alphatricalcium phosphate alpha-TCP were investigated in a bone repair model using a rat model. Methods The potential of alpha-TCP on bone repair was compared to autogenous bone grafting and unfilled cavities were used as negative control. Surgical cavities were prepared and designated as test T implanted with alpha-TCP blocks negative control C - unfilled and positive control C implanted with autogenous bone graft. Results were analyzed on postoperative days three seven 14 21 and 60. Results The histological analyses showed the following results. Postoperative day three presence of inflammatory infiltrate erythrocytes and proliferating fibroblasts in T C - and C samples. Day seven extensive bone neoformation in groups T and C and beginning of alpha-TCP resorption by phagocytic cells. Days 14 and 21 osteoblastic activity in the three types of cavities. Day 60 In all samples neoformed bone similar to surrounding bone. Moderate interruption on the ostectomized cortical bone. Conclusions Bone neoformation is seen seven days after implantation of alpha-TCP and autogenous bone. Comparison of C - with T and C samples showed that repair is faster in implanted cavities on day 60 control groups presented almost complete bone repair. Alpha-TCP cement presents biocompatibility and osteotransductivity besides stability but 60 days after surgery the cavities were not closed. Background Bone exists in two main structural types primary bone and lamellar or secondary bone 1 . Bone repair occurs in a process that may take .