tailieunhanh - Báo cáo y học: "Association between isotretinoin use and central retinal vein occlusion in an adolescent with minor predisposition for thrombotic incidents: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Association between isotretinoin use and central retinal vein occlusion in an adolescent with minor predisposition for thrombotic incidents: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Association between isotretinoin use and central retinal vein occlusion in an adolescent with minor predisposition for thrombotic incidents a case report Georgios Labiris 1 Andreas Katsanos1 Maria Karapetsa2 Ioanna Mpanaka2 and Dimitrios Chatzoulis1 Address Ophthalmology Department University Hospital of Larissa 41110 Larissa Greece and 2Internal Medicine Department University Hospital of Larissa 41110 Larissa Greece Email Georgios Labiris - labiris@ Andreas Katsanos - andreakatbp@ Maria Karapetsa - mkarapetsa@ Ioanna Mpanaka - impanaka@ Dimitrios Chatzoulis - Corresponding author Published 10 February 2009 Received 10 April 2008 Journal of Medical Case Reports 2009 3 58 doi 1752-1947-3-58 Accepted 10 February 2009 This article is available from http content 3 1 58 2009 Labiris et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction We report an adolescent boy with minimal pre-existing risk for thromboses who suffered central retinal vein occlusion associated with isotretinoin use for acne. To the best of our knowledge this is the first well documented case of this association. Case presentation An otherwise healthy 17-year-old white man who was treated with systemic isotretinoin for recalcitrant acne was referred with central retinal vein occlusion in one eye. Although a detailed investigation was negative DNA testing revealed that the patient was a heterozygous carrier of the G20210A mutation of the prothrombin gene. Despite the fact that this particular mutation is thought to represent only a minor risk factor for thromboses it is probable