tailieunhanh - Báo cáo y học: "The Proteomic Code: a molecular recognition code for proteins"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "The Proteomic Code: a molecular recognition code for proteins | Theoretical Biology and Medical Modelling BioMed Central Open Access Review The Proteomic Code a molecular recognition code for proteins Jan C Biro Address Homulus Foundation 88 Howard 1205 San Francisco CA 94105 USA Email Jan C Biro - Published 13 November 2007 Received 2 September 2007 __J AA . AA A. - AKK-A A AT A-AnAACAAA-AA-AAArA-AAAr Accepted 13 November 2007 Theoretical Biology and Medical Modelling 2007 4 45 doi 1742-4682-4-45 This article is available from http content 4 1 45 2007 Biro licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The Proteomic Code is a set of rules by which information in genetic material is transferred into the physico-chemical properties of amino acids. It determines how individual amino acids interact with each other during folding and in specific protein-protein interactions. The Proteomic Code is part of the redundant Genetic Code. Review The 25-year-old history of this concept is reviewed from the first independent suggestions by Biro and Mekler through the works of Blalock Root-Bernstein Siemion Miller and others followed by the discovery of a Common Periodic Table of Codons and Nucleic Acids in 2003 and culminating in the recent conceptualization of partial complementary coding of interacting amino acids as well as the theory of the nucleic acid-assisted protein folding. Methods and conclusions A novel cloning method for the design and production of specific high-affinity-reacting proteins SHARP is presented. This method is based on the concept of proteomic codes and is suitable for large-scale industrial production of specifically interacting peptides. Background Nucleic acids and proteins are the carriers of most if .

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