tailieunhanh - Báo cáo y học: " Hypertabastic survival model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Hypertabastic survival model | Theoretical Biology and Medical Modelling BioMed Central Research Hypertabastic survival model Mohammad A Tabatabai1 Zoran Bursac 2 David K Williams2 and Karan P Singh3 Open Access Address Department of Mathematical Sciences Cameron University Lawton OK USA 2Department of Biostatistics University of Arkansas for Medical Sciences Little Rock AR USA and 3Department of Biostatistics University of North Texas Health Science Center TX USA Email Mohammad ATabatabai - mtabatabai@ Zoran Bursac - zbursac@ David K Williams - dkwilliams@ Karan P Singh - ksingh@ Corresponding author Published 26 October 2007 Received 5 March 2007 Theoretical Biology and Medical Modelling 2007 4 40 doi 1742-4682-4-40 Accepted 26 October 2007 This article is available from http content 4 1 40 2007 Tabatabai et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract A new two-parameter probability distribution called hypertabastic is introduced to model the survival or time-to-event data. A simulation study was carried out to evaluate the performance of the hypertabastic distribution in comparison with popular distributions. We then demonstrate the application of the hypertabastic survival model by applying it to data from two motivating studies. The first one demonstrates the proportional hazards version of the model by applying it to a data set from multiple myeloma study. The second one demonstrates an accelerated failure time version of the model by applying it to data from a randomized study of glioma patients who underwent radiotherapy treatment with and without radiosensitizer misonidazole. Based on the results from the simulation study and two applications the proposed .