tailieunhanh - Báo cáo y học: " Type XVIII collagen degradation products in acute lung injury"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Type XVIII collagen degradation products in acute lung injury. | Available online http content 13 2 R52 Research Type XVIII collagen degradation products in acute lung injury Gavin D Perkins1 4 Nazim Nathani1 Alex G Richter1 Daniel Park1 4 Murali Shyamsundar5 Ritva Heljasvaara2 Taina Pihlajaniemi2 Mav Manji3 W Tunnicliffe3 Danny McAuley5 Fang Gao4 and David R Thickett6 Open Access 1 _ung Injury and Fibrosis Treatment Program LIFT Department of Medical Sciences The Medical School University of Birmingham Edgbaston Birmingham B15 2TT UK 9 IO 11 oil y 2Collagen Research Unit Department of Medical Biochemistry and Molecular Biology University of Oulu Oulu FIN-90014 Finland 3Department of Intensive Care University Hospital Birmingham Edgbaston Birmingham B15 2TH UK 4Department of Anaesthesia and Intensive Care Birmingham Heartlands Hospital Birmingham B9 5SS UK 5Respiratory Medicine Research Cluster Centre for Infection and Immunity Microbiology Building The Queen s University of Belfast Grosvenor Road Belfast BT12 6BN Northern Ireland UK 6Lung Investigation Unit Queen Elizabeth Hospital Birmingham B15 2TH UK Contributed equally Corresponding author David RThickett Received 31 Dec 2008 Revisions requested 26 Jan 2009 Revisions received 19 Mar 2009 Accepted 9 Apr 2009 Published 9 Apr 2009 Critical Care 2009 13 R52 doi cc7779 This article is online at http content 13 2 R52 2009 Perkins et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction In acute lung injury repair of the damaged alveolar-capillary barrier is an essential part of recovery. Endostatin is a 20 to 28 kDa proteolytic fragment of the basement membrane collagen XVIII which has been shown to inhibit angiogenesis via action on endothelial cells. We .