tailieunhanh - Báo cáo y học: " Cable properties and propagation velocity in a long single chain of simulated myocardial cells"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Cable properties and propagation velocity in a long single chain of simulated myocardial cells | BioMed Central Theoretical Biology and Medical Modelling Research Open Access Cable properties and propagation velocity in a long single chain of simulated myocardial cells Lakshminarayanan Ramasamy1 and Nicholas Sperelakis 2 Address 1Dept. of Electrical and Computer Engineering University of Cincinnati College of Engineering Cincinnati OH 45219 USA and 2Dept. of Molecular Cellular Physiology University of Cincinnati College of Medicine Cincinnati OH 45267-0576 USA Email Lakshminarayanan Ramasamy - ramasal@ Nicholas Sperelakis - spereln@ Corresponding author Published 14 September 2007 Received 10 May 2007 T s n __ . ftftft-7 . I I ft 1 . ftft A Accepted 14 September 2007 Theoretical Biology and Medical Modelling 2007 4 36 doi 1742-4682-4-36 This article is available from http content 4 1 36 2007 Ramasamy and Sperelakis licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Propagation of simulated action potentials APs was previously studied in short single chains and in two-dimensional sheets of myocardial cells 1-3 . The present study was undertaken to examine propagation in a long single chain of cells of various lengths and with varying numbers of gap-junction g-j channels and to compare propagation velocity with the cable properties such as the length constant X . Methods and Results Simulations were carried out using the PSpice program as previously described. When the electric field EF mechanism was dominant 0 1 and 10 gj-channels the longer the chain length the faster the overall velocity ớov . There seems to be no simple explanation for this phenomenon. In contrast when the local-circuit current mechanism was dominant 100 gj-channels or .

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