tailieunhanh - Báo cáo y học: "Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges?"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges? | Theoretical Biology and Medical Modelling BioMed Central Open Access Could increased axial wall stress be responsible for the development of atheroma in the proximal segment of myocardial bridges Pierre-André Doriot Pierre-André Dorsaz and Jacques Noble Address Cardiology Department University Hospital Geneva Switzerland Email Pierre-André Doriot - Pierre-André Dorsaz - Jacques Noble - noblej@ Corresponding author Published 9 August 2007 Received II April 2007 Theoretical Biology and Medical Modelling 2007 4 29 doi 1742-4682-4-29 Accepted 9 August 2007 This article is available from http content 4 1 29 2007 Doriot et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background A recent model describing the mechanical interaction between a stenosis and the vessel wall has shown that axial wall stress can considerably increase in the region immediately proximal to the stenosis during the forward flow phases so that abnormal biological processes and wall damages are likely to be induced in that region. Our objective was to examine what this model predicts when applied to myocardial bridges. Method The model was adapted to the hemodynamic particularities of myocardial bridges and used to estimate by means of a numerical example the cyclic increase in axial wall stress in the vessel segment proximal to the bridge. The consistence of the results with reported observations on the presence of atheroma in the proximal tunneled and distal vessel segments of bridged coronary arteries was also examined. Results 1 Axial wall stress can markedly .

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