tailieunhanh - Báo cáo y học: "Fatal fulminant herpes simplex hepatitis secondary to tongue piercing in an immunocompetent adult: a case report"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Fatal fulminant herpes simplex hepatitis secondary to tongue piercing in an immunocompetent adult: a case report | Journal of Medical Case Reports BioMed Central Open Access Case report Fatal fulminant herpes simplex hepatitis secondary to tongue piercing in an immunocompetent adult a case report Shaheen E Lakhan and Lindsey Harle Address Global Neuroscience Initiative Foundation Los Angeles CA USA Email Shaheen E Lakhan - slakhan@ Lindsey Harle - lharle@ Corresponding author Published 20 November 2008 Received 22 January 2008 _ r-_nmno J. .IA I lo mri iQ - - rz Accepted 20 November 2008 Journal of Medical Case Reports 2008 2 356 doi 186 1752-1947-2-356 This article is available from http content 2 1 356 2008 Lakhan and Harle licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Herpes simplex infection is most commonly a benign self-limiting disease with mucocutaneous lesions and mild viremia. Immunosuppressed patients are at a higher risk of disseminated infection as are neonates and pregnant women. The incidence of fulminant herpes simplex virus hepatitis is extremely low and the diagnosis is often missed due to the lack of specific signs or symptoms. Case presentation We present the case of an immunocompetent previously healthy young woman who contracted herpes simplex virus presumably through a recent tongue piercing which progressed to fulminant hepatitis and death. Conclusion Despite aggressive medical therapy fulminant herpes simplex virus hepatitis is fatal in the majority of patients. We present a review of the literature which shows that immunocompetent adults have rarely been affected by fulminant herpes simplex virus hepatitis. Initiation of empirical therapy is warranted in patients with progressive hepatic failure with no other underlying cause. Acyclovir