tailieunhanh - Báo cáo y học: " Biological effects of deuteronation: ATP synthase as an example"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Biological effects of deuteronation: ATP synthase as an example | Theoretical Biology and Medical Modelling BioMed Central Research Biological effects of deuteronation ATP synthase as an example Abdullah Olgun Open Access Address Biochemistry Laboratory TSK Rehabilitation Center Gulhane School of Medicine 06800 Bilkent Ankara Turkey Email Abdullah Olgun - aolgun@ Corresponding author Published 22 February 2007 Theoretical Biology and Medical Modelling 2007 4 9 doi l 742-4682-4-9 Received 26 January 2007 Accepted 22 February 2007 This article is available from http content 4 l 9 2007 Olgun licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In nature deuterium hydrogen ratio is l 6600 therefore one of 3300 water H2O molecules is deuterated HOD D2O . In body fluids the ratio of deuterons to protons is l l5000 because of the lower ionization constant of heavy water. The probability of deuteronation rather than protonation of Asp 6l on the subunit c of F0 part of ATP synthase is also l l5000. The contribution of deuteronation to the pKa of Asp 6l is . Theory and Discussion In mitochondria the release of a deuteron into the matrix side halfchannel of F0 is likely to be slower than that of a proton. As another example deuteronation may slow down electron transfer in the electron transport chain ETC by interfering with proton coupled electron transport reactions PCET and increase free radical production through the leakage of temporarily accumulated electrons at the downstream complexes. Conclusion Deuteronation as exemplified by ATP synthase and the ETC may interfere with the conformations and functions of many macromolecules and contribute to some pathologies like heavy water toxicity and aging. Background Deuteronation In nature the ratio .