tailieunhanh - Báo cáo y học: " Immunostimulation and Immunoinhibition of Premalignant Lesions"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Immunostimulation and Immunoinhibition of Premalignant Lesions | Theoretical Biology and Medical Modelling BioMed Central Open Access Review Immunostimulation and Immunoinhibition of Premalignant Lesions Richmond T Prehn Address Department of Pathology University of Washington 5433 South Hudson St Seattle WA 98118 USA Email Richmond T Prehn - prehn@ Corresponding author Published 6 February 2007 Received 24 November 2006 Theoretical Biology and Medical Modelling 2007 4 6 doi 1742-4682-4-6 Accepted 6 February 2007 This article is available from http content 4 1 6 2007 Prehn licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The immune reaction may be either stimulatory or inhibitory to tumor growth depending upon the local ratio of immune reactants to tumor cells. Hypothesis A tumor-stimulatory immune response may be essential for survival of a neoplasm in vivo and for the biological progression from a premalignant lesion to a malignancy. Neither a positive nor a negative correlation between the magnitude of an immune-cell infiltrate and a cancer s prognosis can reveal whether the infiltrate was stimulating or inhibiting to the tumor s growth unless the position on the nonlinear curve that relates tumor growth to the magnitude of the immune reaction is known. Discussion This hypothesis is discussed in relation to the development of human malignant melanomas and colorectal cancers. Background The dose-response curve ICR relating the magnitude of the immune reaction to tumor growth is not linear at least in the mouse Figure 1 . The fact that an immune reaction may under some circumstances act to enhance rather than inhibit neoplastic growth has been known for many years 1 . The first convincing demonstration that more might be .

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