tailieunhanh - Báo cáo y học: "The biological sense of cancer: a hypothesis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The biological sense of cancer: a hypothesis | Theoretical Biology and Medical Modelling Research The biological sense of cancer a hypothesis Raúl A Ruggiero and Oscar D Bustuoabad BioMed Central Open Access Address División Medicina Experimental Instituto de Investigaciones Hematológicas Academia Nacional de Medicina de Buenos Aires Pacheco de Melo 3081 1425 Buenos Aires Argentina Email Raúl A Ruggiero - ruloruggiero@ Oscar D Bustuoabad - busdao@ Corresponding author Published 15 December 2006 Received 25 September 2006 Theoretical Biology and Medical Modelling 2006 3 43 doi 1742-4682-3-43 Accepted 15 December 2006 This article is available from http content 3 1 43 2006 Ruggiero and Bustuoabad licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Most theories about cancer proposed during the last century share a common denominator cancer is believed to be a biological nonsense for the organism in which it originates since cancer cells are believed to be ones evading the rules that control normal cell proliferation and differentiation. In this essay we have challenged this interpretation on the basis that throughout the animal kingdom cancer seems to arise only in injured organs and tissues that display lost or diminished regenerative ability. Hypothesis According to our hypothesis a tumor cell would be the only one able to respond to the demand to proliferate in the organ of origin. It would be surrounded by normal aged cells that cannot respond to that signal. According to this interpretation cancer would have a profound biological sense it would be the ultimate way to attempt to restore organ functions and structures