tailieunhanh - Báo cáo y học: "In silico experimentation with a model of hepatic mitochondrial folate metabolism"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " In silico experimentation with a model of hepatic mitochondrial folate metabolism | Theoretical Biology and Medical Modelling BioMed Central Research In silico experimentation with a model of hepatic mitochondrial folate metabolism H Frederik Nijhout 1 Michael C Reed2 Shi-Ling Lam1 Barry Shane3 Jesse F Gregory III4 and Cornelia M Ulrich5 Open Access Address Department of Biology Duke University Durham NC 27708 USA 2Department of Mathematics Duke University Durham NC 27708 USA 3Department of Nutrition Sciences and Toxicology University of California Berkeley CA 94720-3104 USA 4Department of Food Science and Human Nutrition University of Florida 32611-0370 USA and 5Cancer Prevention Program Fred Hutchinson Cancer Research Center Seattle WA 98109-1024 USA Email H Frederik Nijhout - hfn@ Michael C Reed - reed@ Shi-Ling Lam - Barry Shane - bandie@ Jesse F Gregory - jfgy@ Cornelia M Ulrich - nulrich@ Corresponding author Published 06 December 2006 Received 20 October 2006 Theoretical Biology and Medical Modelling 2006 3 40 doi 1742-4682-3-40 Accepted 06 December 2006 This article is available from http content 3 1 40 2006 Nijhout et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background In eukaryotes folate metabolism is compartmentalized and occurs in both the cytosol and the mitochondria. The function of this compartmentalization and the great changes that occur in the mitochondrial compartment during embryonic development and in rapidly growing cancer cells are gradually becoming understood though many aspects remain puzzling and controversial. Approach We explore the properties of cytosolic and mitochondrial folate .