tailieunhanh - Báo cáo y học: "Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats. | Available online http content 13 4 R109 Research Thoracic epidural anesthesia time-dependently modulates pulmonary endothelial dysfunction in septic rats Stefan Lauer1 Hendrik Freise1 Martin Westphal1 Alexander Zarbock1 Manfred Fobker2 Hugo K Van Aken1 Andreas W Sielenkamper1 and Lars G Fischer1 Department of Anesthesiology and Intensive Care Medicine University Hospital Muenster Albert-Schweitzer-Str. 33 48149 Muenster Germany 2Center for Laboratory Medicine University Hospital of Muenster Albert-Schweitzer-Str. 33 48149 Muenster Germany Corresponding author Stefan Lauer stlauer@ Received 13 Mar 2009 Revisions requested 5 May 2009 Revisions received 2 Jun 2009 Accepted 6 Jul 2009 Published 6 Jul 2009 Critical Care 2009 13 R109 doi cc7950 This article is online at http content 13 4 R1 09 2009 Lauer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Increasing evidence indicates that epidural anesthesia improves postoperative pulmonary function. The underlying mechanisms however remain to be determined. Because pulmonary nitric oxide has been identified to play a critical role in pulmonary dysfunction in sepsis we hypothesized that thoracic epidural anesthesia TEA modulates endothelial dysfunction via a nitric oxide-dependent pathway. Methods Thirty-six Sprague-Dawley rats underwent sham laparotomy or induction of peritoneal sepsis caused by cecal ligation and puncture CLP . Septic animals were then treated with either bupivacaine or normal saline epidurally 15 pl h-1 for 6 hours or 24 hours after injury. Previous experiments demonstrated that these time points correspond with a hyperdynamic at 6 hours and hypodynamic circulation at 24 hours .