tailieunhanh - Báo cáo y học: "Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients. | Available online http content 13 1 R26 Research Clinical relevance of the severe abnormalities of the T cell compartment in septic shock patients Jorge Monserrat1 Raul de Pablo2 Eduardo Reyes1 David Diaz1 Hugo Barcenilla1 Manuel R Zapata1 Antonio De la Hera1 Alfredo Prieto1 and Melchor Alvarez-Mon1 3 Open Access Laboratory of Immune System Diseases and Oncology National Biotechnology Center - Department of Medicine CNB-CSIC Associated Unit University of Alcalá Alcalá de Henares 28871 Madrid Spain intensive Care Unit Hospital Universitario Príncipe de Asturias Alcalá de Henares 28871 Madrid Spain 3Immune System Diseases and Oncology Service Hospital Universitario Príncipe de Asturias Alcalá de Henares 28871 Madrid Spain Contributed equally Corresponding author Jorge Monserrat Received 14 Nov 2008 Revisions requested 23 Dec 2008 Revisions received 20 Jan 2009 Accepted 25 Feb 2009 Published 25 Feb 2009 Critical Care 2009 13 R26 doi cc7731 This article is online at http content 13 1 R26 2009 Monserrat et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Given the pivotal role of T lymphocytes in the immune system patients with septic shock may show T cell abnormalities. We have characterised the T cell compartment in septic shock and assess its clinical implications. Methods T lymphocytes from the peripheral blood of 52 patients with septic shock and 36 healthy control subjects were analysed on admission to the intensive care unit baseline and 3 7 14 and 28 days later. T cell phenotypes CD3 CD4 CD3 CD8 CD45RA CD45RO CD62L CD28 were assessed by quantitative flow cytometry. Results CD3 CD3 CD4 and CD3 CD8 lymphocyte counts were significantly lower in .