tailieunhanh - Báo cáo y học: " A reaction-diffusion model of the receptor-toxinantibody interaction"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:A reaction-diffusion model of the receptor-toxinantibody interaction | Skakauskas et al. Theoretical Biology and Medical Modelling 2011 8 32 http content 8 1 32 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access A reaction-diffusion model of the receptor-toxin-antibody interaction Vladas Skakauskas1 Pranas Katauskis1 and Alex Skvortsov2 Correspondence alex. skvortsov@ 2HPP Division Defence Science and Technology Organisation 506 Lorimer st. VIC 3207 Melbourne Australia Full list of author information is available at the end of the article Qy BioMed Central Abstract Background It was recently shown that the treatment effect of an antibody can be described by a consolidated parameter which includes the reaction rates of the receptor-toxin-antibody kinetics and the relative concentration of reacting species. As a result any given value of this parameter determines an associated range of antibody kinetic properties and its relative concentration in order to achieve a desirable therapeutic effect. In the current study we generalize the existing kinetic model by explicitly taking into account the diffusion fluxes of the species. Results A refined model of receptor-toxin-antibody RTA interaction is studied numerically. The protective properties of an antibody against a given toxin are evaluated for a spherical cell placed into a toxin-antibody solution. The selection of parameters for numerical simulation approximately corresponds to the practically relevant values reported in the literature with the significant ranges in variation to allow demonstration of different regimes of intracellular transport. Conclusions The proposed refinement of the RTA model may become important for the consistent evaluation of protective potential of an antibody and for the estimation of the time period during which the application of this antibody becomes the most effective. It can be a useful tool for in vitro selection of potential protective antibodies for progression to in vivo evaluation. 1. Background The .