tailieunhanh - Báo cáo y học: " Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling: model structure and parameters determination | Theoretical Biology and Medical BioMed Zentral Modelling Research Open Access Assessing drug distribution in tissues expressing P-glycoprotein through physiologically based pharmacokinetic modeling model structure and parameters determination Frédérique Fenneteau1 Jacques Turgeon1 Lucie Couture1 2 Véronique Michaud1 Jun Li3 4 and Fahima Nekka 1 3 Address 1Faculté de Pharmacie Université de Montréal Montréal Québec Canada 2Charles River Laboratories Preclinical Services Montréal Inc. Montréal Québec Canada 3Centre de Recherche Mathématiques Université de Montréal Montréal Québec Canada and 4Pharsight Montréal Québec Canada E-mail Frédérique Fenneteau - Jacques Turgeon - Lucie Couture - lcouture@ Véronique Michaud - Jun Li - li@ Fahima Nekka - Corresponding author Published 15 January 2009 Received 17 September 2008 Theoretical Biology and Medical Modelling 2009 6 2 doi 186 1742-4682-6-2 ccepted 15 January 2009 This article is available from http content 6 1 2 2009 Fenneteau et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The expression and activity of P-glycoproteins due to genetic or environmental factors may have a significant impact on drug disposition drug effectiveness or drug toxicity. Hence characterization of drug disposition over a wide range of conditions of these membrane transporters activities is required to better characterize drug pharmacokinetics and pharmacodynamics. This work aims to improve our understanding of the impact of P-gp activity modulation on tissue distribution of P-gp substrate. Methods A PBPK model was .