tailieunhanh - Báo cáo y học: "Understanding genetics of sepsis: will new technology help"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Understanding genetics of sepsis: will new technology help? | Available online http content 13 3 141 Commentary Understanding genetics of sepsis will new technology help Sachin Yende1 2 and John A Kellum1 2 1The Clinical Research Investigation and Systems Modeling of Acute Illness CRISMA Laboratory University of Pittsburgh Pittsburgh PA 15261 USA 2Department of Critical Care Medicine 604 Scaife Hall University of Pittsburgh School of Medicine 3550 Terrace Street Pittsburgh PA 15261 USA Corresponding author John A Kellum kellumja@ Published 6 May 2009 This article is online at http content 13 3 141 2009 BioMed Central Ltd Critical Care 2009 13 141 doi cc7727 See related review by Sutherland and Walley http content 13 2 210 Abstract High-throughput techniques such as genome-wide scans will allow genotyping of a large number of single-nucleotide polymorphisms throughout the human genome. There is intense interest to apply this technology to understand genetics of complex traits including severe sepsis. To effectively utilize this technology large cohorts of septic patients will have to be recruited. Careful attention should be paid to different aspects of study design and analyses as large multicenter cohorts are assembled for genome-wide association studies. Resistance to infection and its outcomes are influenced by a complex interplay between the host the microbe and the environment. Severe sepsis occurs due to abnormalities in the host response to infection. There is great interest to understand whether genetic determinants of the host response to infection are associated with poor outcomes of infection. Identifying these genetic determinants could be important to improve performance of current risk prediction models. Furthermore the pharmacogenomics of sepsis will allow us to target immune-modulating therapies. Despite these plausible benefits and more than a decade of research the role of genetic determinants in severe sepsis remains unclear. Results of some studies have .