tailieunhanh - Báo cáo y học: "NICE-SUGAR: the end of a sweet dream"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: NICE-SUGAR: the end of a sweet dream? | Available online http content 13 3 143 Commentary NICE-SUGAR the end of a sweet dream Jean-Charles Preiser Department of Intensive Care Centre Hospitalier Universitaire du Sart Tilman 4000 Liege Belgium. Corresponding author Jean-Charles Preiser Published 14 May 2009 This article is online at http content 13 3 143 2009 BioMed Central Ltd Critical Care 2009 13 143 doi cc7790 Abstract The results of the NICE-SUGAR Normoglycaemia in Intensive Care Evaluation Survival Using Glucose Algorithm Regulation trial were released last March. The primary outcome variable 90-day mortality was actually increased in patients randomly assigned to intensive insulin therapy as compared with an intermediate target range for blood glucose. These findings reflecting data collected in a set of more than 6 000 patients clearly refute the external validity of tight glucose control. Future research will probably focus on several questions raised by the divergent results reported from investigations in the field of glucose control in the critically ill. On Tuesday 24 March 2009 at 10 05 hours the Erasmus Room of the Exhibition and Congress Centre of Brussels was overcrowded. Attendees from all over the world had gathered for a well planned and widely announced event. Professor Simon Finfer from the Royal North Shore Hospital of Sydney Australia was about to release the results of the NICE-SUGAR Normoglycaemia in Intensive Care Evaluation Survival Using Glucose Algorithm Regulation trial the largest clinical study conducted in critical care medicine to date. At the end of his presentation the article was published and available on the website of the New England Journal of Medicine 1 . NICE-SUGAR was designed to test whether tight glucose control by intensive insulin therapy TGCIIT n 3 010 evaluable patients increases 90-day survival as compared with less strict glucose control n 3 012 evaluable patients . The issue of TGCIIT .