tailieunhanh - Báo cáo y học: "Changes in serum adiponectin concentrations in critical illness: a preliminary investigation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Changes in serum adiponectin concentrations in critical illness: a preliminary investigation. | Available online http content 13 4 R105 Research Changes in serum adiponectin concentrations in critical illness a preliminary investigation Bala Venkatesh1 Ingrid Hickman2 Janelle Nisbet2 Jeremy Cohen3 and John Prins2 Open Access 1 Department of Intensive Care Princess Alexandra Wesley Hospitals University of Queensland Ipswich Road QLD 4102 Woolloongabba Australia 2Department of Endocrinology Princess Alexandra Hospital University of Queensland Ipswich Road QLD 4102 Woolloongabba Australia department of Intensive Care Royal Brisbane Hospital University of Queensland Butterfield Street Herston Road Herston QLD 4029 Brisbane Australia Corresponding author Bala Venkatesh bala_venkatesh@ Received 24 Apr 2009 Revisions requested 15 May 2009 Revisions received 8 Jun 2009 Accepted 2 Jul 2009 Published 2 Jul 2009 Critical Care 2009 13 R105 doi cc7941 This article is online at http content 13 4 R1 05 2009 Venkatesh et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Adiponectin plays an important role in the regulation of tissue inflammation and insulin sensitivity. Perturbations in adiponectin concentration have been associated with obesity and the metabolic syndrome. Data on adiponectin pathophysiology in critical illness are limited. Methods Twenty three critically ill patients 9 severe sepsis 7 burns 7 trauma . Adiponectin assays on Days 3 D3 and 7 D7 . Simultaneous cortisol cortisone and CRP measurements. Data from 16 historical controls were used for comparison. Results The mean plasma adiponectin concentration for the ICU cohort on D3 and D7 were not significantly different and mcg ml respectively P . However these were .