tailieunhanh - Báo cáo y học: " Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài:Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy | Schneider et al. Theoretical Biology and Medical Modelling 2011 8 27 http content 8 1 27 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Site-specific dose-response relationships for cancer induction from the combined Japanese A-bomb and Hodgkin cohorts for doses relevant to radiotherapy Uwe Schneider1 2 Marcin Sumila1 and Judith Robotka1 Correspondence uschneider@ Radiotherapy Hirslanden AG Institute for Radiotherapy Rain 34 5001 Aarau Switzerland Full list of author information is available at the end of the article 2 BioMed Central Abstract Background and Purpose Most information on the dose-response of radiation-induced cancer is derived from data on the A-bomb survivors. Since for radiation protection purposes the dose span of main interest is between zero and one Gy the analysis of the A-bomb survivors is usually focused on this range. However estimates of cancer risk for doses larger than one Gy are becoming more important for radiotherapy patients. Therefore in this work emphasis is placed on doses relevant for radiotherapy with respect to radiation induced solid cancer. Materials and methods For various organs and tissues the analysis of cancer induction was extended by an attempted combination of the linear-no-threshold model from the A-bomb survivors in the low dose range and the cancer risk data of patients receiving radiotherapy for Hodgkin s disease in the high dose range. The data were fitted using organ equivalent dose OED calculated for a group of different dose-response models including a linear model a model including fractionation a bell-shaped model and a plateau-dose-response relationship. Results The quality of the applied fits shows that the linear model fits best colon cervix and skin. All other organs are best fitted by the model including fractionation indicating that the repopulation repair ability of tissue is neither 0 nor 100 but somewhere in between. Bone and soft tissue sarcoma were .