tailieunhanh - Báo cáo y học: "Respiratory and haemodynamic changes during decremental open lung positive end-expiratory pressure titration in patients with acute respiratory distress syndrome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Respiratory and haemodynamic changes during decremental open lung positive end-expiratory pressure titration in patients with acute respiratory distress syndrome. | Available online http content 13 2 R59 Research Respiratory and haemodynamic changes during decremental open lung positive end-expiratory pressure titration in patients with acute respiratory distress syndrome Christian Gernoth1 Gerhard Wagner2 Paolo Pelosi3 and Thomas Luecke1 1 Department of Anesthesiology and Critical Care Medicine University Hospital Mannheim Faculty of Medicine University of Heidelberg Theodor-Kutzer Ufer 68165 Mannheim Germany department of Anesthesiology an Critical Care Medicine Robert-Bosch Hospital Auerbachstrasse 110 70376 Stuttgart Germany department of Ambient Health and Safety University of Insubria c o Villa Toeplitz Via . Vico 46 21100 Varese Italy Corresponding author Thomas Luecke Received 7 Jan 2009 Revisions requested 23 Feb 2009 Revisions received 6 Mar 2009 Accepted 17 Apr 2009 Published 1 7 Apr 2009 Critical Care 2009 13 R59 doi cc7786 This article is online at http content 13 2 R59 2009 Gernoth et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction To investigate haemodynamic and respiratory changes during lung recruitment and decremental positive end-expiratory pressure PEEP titration for open lung ventilation in patients with acute respiratory distress syndrome ARDS a prospective clinical trial was performed involving 12 adult patients with ARDS treated in the surgical intensive care unit in a university hospital. Methods A software programme Open Lung Tool incorporated into a standard ventilator controlled the recruitment pressure-controlled ventilation with fixed PEEP at 20 cmH2O and increased driving pressures at 20 25 and 30 cmH2O for two minutes each and PEEP titration