tailieunhanh - Báo cáo y học: "Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection. | Available online http content 13 3 R101 Research Macrophage migration inhibitory factor in cerebrospinal fluid from patients with central nervous system infection Christian Ostergaard1 and Thomas Benfield2 3 Department of Clinical Microbiology Copenhagen University Hospital Herlev Herlev Ringvej DK-2730 Herlev Denmark department of Infectious Diseases and Clinical Research Centre Hvidovre University Hospital Kettegảrds Alle 2650 Hvidovre Denmark 3Faculty of Health Sciences University of Copenhagen Blegdamsvej 2200 Copenhagen N Denmark Corresponding author Christian Ostergaard coa@ Received 28 Apr 2009 Revisions requested 5 Jun 2009 Revisions received 22 Jun 2009 Accepted 26 Jun 2009 Published 26 Jun 2009 Critical Care 2009 13 R101 doi cc7933 This article is online at http content 13 3 R1 01 2009 Ostergaard et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Macrophage migration inhibitory factor MIF plays an essential pathophysiological role in septic shock but its role in central nervous system infection CNS remains to be defined. Methods We investigated cerebrospinal fluid CSF levels of MIF in 171 patients who were clinically suspected of having meningitis on admission. Of these 31 were found to have purulent meningitis of known aetiology 20 purulent meningitis of unknown aetiology 59 lymphocytic meningitis and 11 encephalitis whereas 50 were suspected of having but had no evidence of CNS infection. Results CSF MIF levels were significantly higher in patients with purulent meningitis of known aetiology median interquartile range 8 639 3 344 to 20 600 ng l than in patients with purulent meningitis of unknown aetiology 2 209 1 516 to 6 550 ng l .