tailieunhanh - Báo cáo y học: " The Peter Pan paradigm"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " The Peter Pan paradigm | Theoretical Biology and Medical Modelling BioMed Central Review The Peter Pan paradigm J Craig Cohen and Janet E Larson Open Access Address The Brady Laboratory Section of Neonatology Department of Pediatrics Stony Brook University Medical Center Stony Brook NY 11794 USA Email J Craig Cohen - Janet E Larson - Corresponding author Published 8 January 2008 Theoretical Biology and Medical Modelling 2008 5 1 doi 1742-4682-5-1 Received 6 June 2007 Accepted 8 January 2008 This article is available from http content 5 1 1 2008 Cohen and Larson licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Genetic and environmental agents that disrupt organogenesis are numerous and well described. Less well established however is the role of delay in the developmental processes that yield functionally immature tissues at birth. Evidence is mounting that organs do not continue to develop postnatally in the context of these organogenesis insults condemning the patient to utilize underdeveloped tissues for adult processes. These poorly differentiated organs may appear histologically normal at birth but with age may deteriorate revealing progressive or adult-onset pathology. The genetic and molecular underpinning of the proposed paradigm reveals the need for a comprehensive systems biology approach to evaluate the role of maternal-fetal environment on organogenesis. You may delay but time will not Benjamin Franklin USA Founding Father Background The fragility of the developmental process is well known with estimates as high as 70 of conceptions lost in early pregnancy 1 . Genetic .