tailieunhanh - Báo cáo y học: " Simulating non-small cell lung cancer with a multiscale agent-based model"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: " Simulating non-small cell lung cancer with a multiscale agent-based model | Theoretical Biology and Medical Modelling BioMed Central Research Simulating non-small cell lung cancer with a multiscale agent-based model Zhihui Wang Le Zhang Jonathan Sagotsky and Thomas S Deisboeck Address Complex Biosystems Modeling Laboratory Harvard-MIT HST Athinoula A. Martinos Center for Biomedical Imaging Massachusetts General Hospital Charlestown MA 02129 USA Email Zhihui Wang - billwang@ Le Zhang - adamzhan@ Jonathan Sagotsky-sagotsky@ Thomas S Deisboeck - deisboec@ Corresponding author Open Access Published 21 December 2007 Received 12 June 2007 Theoretical Biology and Medical Modelling 2007 4 50 doi 1742-4682-4-50 Accepted 21 December 2007 This article is available from http content 4 1 50 2007 Wang et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The epidermal growth factor receptor EGFR is frequently overexpressed in many cancers including non-small cell lung cancer NSCLC . In silico modeling is considered to be an increasingly promising tool to add useful insights into the dynamics of the EGFR signal transduction pathway. However most of the previous modeling work focused on the molecular or the cellular level only neglecting the crucial feedback between these scales as well as the interaction with the heterogeneous biochemical microenvironment. Results We developed a multiscale model for investigating expansion dynamics of NSCLC within a two-dimensional in silico microenvironment. At the molecular level a specific EGFR-ERK intracellular signal transduction pathway was implemented. Dynamical alterations of these molecules were used to trigger phenotypic changes at the cellular .