tailieunhanh - Báo cáo y học: "Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: "Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment | Theoretical Biology and Medical Modelling BioMed Central Research Open Access Simulation of propofol anaesthesia for intracranial decompression using brain hypothermia treatment Lu Gaohua t and Hidenori Kimurat Address Bio-Mimetic Control Research Center The Institute of Physical and Chemical Research RIKEN Nagoya 463-0003 Japan Email Lu Gaohua - lu@ Hidenori Kimura - kimura@ Corresponding author fEqual contributors Published 29 November 2007 Received 7 November 2007 Accepted 29 November 2007 Theoretical Biology and Medical Modelling 2007 4 46 doi 1742-4682-4-46 r This article is available from http content 4 1 46 2007 Gaohua and Kimura licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Although propofol is commonly used for general anaesthesia of normothermic patients in clinical practice little information is available in the literature regarding the use of propofol anaesthesia for intracranial decompression using brain hypothermia treatment. A novel propofol anaesthesia scheme is proposed that should promote such clinical application and improve understanding of the principles of using propofol anaesthesia for hypothermic intracranial decompression. Methods Theoretical analysis was carried out using a previously-developed integrative model of the thermoregulatory hemodynamic and pharmacokinetic subsystems. Propofol kinetics is described using a framework similar to that of this model and combined with the thermoregulation subsystem through the pharmacodynamic relationship between the blood propofol concentration and the thermoregulatory threshold. A propofol anaesthesia scheme for hypothermic intracranial decompression was simulated using the integrative .