tailieunhanh - Báo cáo y học: "Cancer proliferation and therapy: the Warburg effect and quantum metabolism"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Cancer proliferation and therapy: the Warburg effect and quantum metabolism. | Demetrius et al. Theoretical Biology and Medical Modelling 2010 7 2 http content 7 1 2 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Cancer proliferation and therapy the Warburg effect and quantum metabolism Lloyd A Demetrius1 Johannes F Coy2 Jack A Tuszynski3 Correspondence jtus@phys. 3Department of Experimental Oncology Cross Cancer Research Institute Edmonton Alberta Canada 2 BioMed Central Abstract Background Most cancer cells in contrast to normal differentiated cells rely on aerobic glycolysis instead of oxidative phosphorylation to generate metabolic energy a phenomenon called the Warburg effect. Model Quantum metabolism is an analytic theory of metabolic regulation which exploits the methodology of quantum mechanics to derive allometric rules relating cellular metabolic rate and cell size. This theory explains differences in the metabolic rates of cells utilizing OxPhos and cells utilizing glycolysis. This article appeals to an analytic relation between metabolic rate and evolutionary entropy - a demographic measure of Darwinian fitness - in order to a provide an evolutionary rationale for the Warburg effect and b propose methods based on entropic principles of natural selection for regulating the incidence of OxPhos and glycolysis in cancer cells. Conclusion The regulatory interventions proposed on the basis of quantum metabolism have applications in therapeutic strategies to combat cancer. These procedures based on metabolic regulation are non-invasive and complement the standard therapeutic methods involving radiation and chemotherapy. Background Cancer is an age-dependent disease characterized by five key hallmarks in cell physiology that drive the progressive change of normal differentiated cells into diverse states of malignancy 1 autonomous growth-replication in the absence of growth signals insensitivity to anti-growth signals apoptosis-evasion of programmed cell death angio-genesis-the induction of the .