tailieunhanh - Báo cáo y học: "Vaginal metastasis of a Ewing sarcoma five years after resection of the primary tumor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Vaginal metastasis of a Ewing sarcoma five years after resection of the primary tumor. | Vanel et al. Clinical Sarcoma Research 2011 1 9 http content 1 1 9 CLINICAL SARCOMA RESEARCH CASE REPORT Open Access Vaginal metastasis of a Ewing sarcoma five years after resection of the primary tumor Noemie Vanel 1 Victoire Vierling1 Jennifer Kreshak1 Marco Gambarotti1 Stefania Cocchi1 Cristina Tranfaglia2 and Daniel Vanel1 Abstract A 35-year-old female presented with pain and swelling of the distal left radius. A diagnosis of Ewing sarcoma was made and she underwent neoadjuvant chemotherapy and surgery. Macroscopic viable areas remained on the map of the surgical specimen as such she was classified as a poor responder and received high dose adjuvant chemotherapy. She remained disease-free for five years until age 40. A vaginal polyp was then detected during a routine gynaecologic examination. It was removed and histopathology revealed metastatic Ewing sarcoma. To our knowledge this is the first reported case of a vaginal metastasis of Ewing sarcoma. Keywords Ewing sarcoma vaginal metastasis Introduction Ewing sarcoma ES is a small blue round cell tumor belonging to the Ewing Family Tumour EFT together with Primary Neuroectodermal Tumour PNET and ASKIN tumor of the thoracic wall . Eight hundred and ninety six cases have been reported in our institute since 1982. Ewing sarcoma has a distinct predilection for males and occurs in the first two decades of life in more than 75 percent of cases 1 2 . Metastases are frequent 3 and are mostly pulmonary and osseous but can be found in various other locations. We present here the first description of a vaginal metastasis of Ewing sarcoma. Case Report A 35 year-old woman with no significant medical history presented with pain and swelling of the left wrist over the past year. A radiograph and computed tomography scan revealed a lytic lesion of the distal left radius Figure 1 with soft tissue extension on MR examination Figure 2 3 . A biopsy was performed and histological examination revealed