tailieunhanh - Báo cáo y học: "Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus. | Theoretical Biology and Medical Modelling BioMed Central Research Using a human cardiovascular-respiratory model to characterize cardiac tamponade and pulsus paradoxus Deepa Ramachandran1 Chuan Luo1 Tony S Ma2 3 and John W Clark Jr 1 Open Access Address Department of Electrical and Computer Engineering Rice University Houston Texas 77005 USA 2Division of Cardiology VA Medical Center Houston Texas 77030 USA and 3Baylor College of Medicine One Baylor Plaza Houston Texas 77030 USA Email Deepa Ramachandran - dpr2@ Chuan Luo - urania@ Tony S Ma - John W Clark - jwc@ Corresponding author Published 6 August 2009 Received 12 February 2009 Theoretical Biology and Medical Modelling 2009 6 15 doi 1742-4682-6-15 Accepted 6 August 2009 This article is available from http content 6 1 15 2009 Ramachandran et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Cardiac tamponade is a condition whereby fluid accumulation in the pericardial sac surrounding the heart causes elevation and equilibration of pericardial and cardiac chamber pressures reduced cardiac output changes in hemodynamics partial chamber collapse pulsus paradoxus and arterio-venous acid-base disparity. Our large-scale model of the human cardiovascular-respiratory system H-CRS is employed to study mechanisms underlying cardiac tamponade and pulsus paradoxus. The model integrates hemodynamics whole-body gas exchange and autonomic nervous system control to simulate pressure volume and blood flow. Methods We integrate a new pericardial model into our previously developed H-CRS model based on a fit to patient pressure data. Virtual experiments are designed to simulate pericardial effusion and .

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