tailieunhanh - Báo cáo y học: "Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. | Available online http content 13 3 R92 Research Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow a prospective study Arnaldo Dubin1 2 Mario O Pozo3 Christian A Casabella1 Fernando Palizas Jr3 Gastón Murias3 Miriam C Moseinco1 Vanina S Kanoore Edul1 2 Fernando Palizas3 Elisa Estenssoro4 and Can Ince5 Open Access 1Servicio de Terapia Intensiva Sanatorio Otamendi y Miroli Azcuenaga 870 Buenos Aires C1115AAB Argentina 2Cátedra de Farmacologia Aplicada Facultad de Ciencias Médicas Universidad Nacional de La Plata 60 y 120 La Plata 1900 Argentina 3Servicio de Terapia Intensiva Clinica Bazterrica Juncal 3002 Buenos Aires C1425AYN Argentina 4Servicio de Terapia Intensiva Hospital San Martin 1 y 70 La Plata 1900 Argentina 5Translational Physiology Academic Medical Center University of Amsterdam Meibergdreef 9 Amsterdam 1105 AZ The Netherlands Corresponding author Arnaldo Dubin arnaldodubin@ Received 5 May 2009 Revisions requested 18 May 2009 Revisions received 25 May 2009 Accepted 17 Jun 2009 Published 1 7 Jun 2009 Critical Care 2009 13 R92 doi cc7922 This article is online at http content 13 3 R92 2009 Dubin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Our goal was to assess the effects of titration of a norepinephrine infusion to increasing levels of mean arterial pressure MAP on sublingual microcirculation. Methods Twenty septic shock patients were prospectively studied in two teaching intensive care units. The patients were mechanically ventilated and required norepinephrine to maintain a mean arterial pressure MAP of 65 mmHg. We measured systemic hemodynamics oxygen transport and consumption DO2 and .