tailieunhanh - Báo cáo y học: "Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury: a cohort study. | Available online http content 13 3 R88 Open Access Research Early down-regulation of the pro-inflammatory potential of monocytes is correlated to organ dysfunction in patients after severe multiple injury a cohort study Chlodwig Kirchhoff1 Peter Biberthaler2 Wolf E Mutschler2 Eugen Faist3 Marianne Jochum4 and Siegfried Zedler3 Department of Orthopaedic Surgery and Traumatology Klinikum Rechts der Isar Technische Universitaet Ismaningerstrasse 22 81 675 Munich Germany department of Orthopaedic Surgery and Traumatology Campus Innenstadt Ludwig-Maximilians Universitaet Nussbaumstrasse 20 80336 Munich Germany department of Surgery Campus Grosshadern Ludwig-Maximilians Universitaet Munich Germany Marchioninistrasse 15 81377 Munich Germany department of Clinical Chemistry and Clinical Biochemistry Campus Innenstadt Ludwig-Maximilians Universitaet Nussbaumstrasse 20 80336 Munich Germany Corresponding author Chlodwig Kirchhoff Received 16 Apr 2009 Revisions requested 14 May 2009 Revisions received 21 May 2009 Accepted 11 Jun 2009 Published 11 Jun 2009 Critical Care 2009 13 R88 doi cc7914 This article is online at http content 13 3 R88 2009 Kirchhoff et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Severe tissue trauma results in a general inflammatory immune response SIRS representing an overall inflammatory reaction of the immune system. However there is little known about the functional alterations of monocytes in the early posttraumatic phase characterized by the battle of the individual with the initial trauma. Methods Thirteen patients with severe multiple injury injury severity score ISS 16 points 17 to 57 were included. The cytokine .