tailieunhanh - Báo cáo y học: "Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Rapid development of intestinal cell damage following severe trauma: a prospective observational cohort study. | Available online http content 13 3 R86 Research Rapid development of intestinal cell damage following severe trauma a prospective observational cohort study Jacco J de Haan1 Tim Lubbers1 Joep P Derikx1 2 Borna Relja3 Dirk Henrich3 Jan- Willem Greve4 1 Ingo Marzi3 and Wim A Buurman1 Open Access 1 Department of Surgery NUTRIM School for Nutrition Toxicology and Metabolism Maastricht University Medical Center Universiteitssingel 50 6229 ER Maastricht The Netherlands department of Surgery Orbis Medisch Centrum Dr. H. van der Hoffplein 1 6162 BG Sittard-Geleen The Netherlands department of Trauma Surgery . Goethe University Theodor-Stern-Kai 7 60590 Frankfurt am Main Germany 4Department of Surgery Atrium Medisch Centrum Henri Dunantstraat 5 6419 PC Heerlen The Netherlands Corresponding author Wim A Buurman Received 24 May 2009 Revisions requested 8 Jun 2009 Revisions received 8 Jun 2009 Accepted 8 Jun 2009 Published 8 Jun 2009 Critical Care 2009 13 R86 doi cc7910 This article is online at http content 13 3 R86 2009 de haan et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Loss of intestinal integrity has been implicated as an important contributor to the development of excessive inflammation following severe trauma. Thus far clinical data concerning the occurrence and significance of intestinal damage after trauma remain scarce. This study investigates whether early intestinal epithelial cell damage occurs in trauma patients and if present whether such cell injury is related to shock injury severity and the subsequent inflammatory response. Methods Prospective observational cohort study in 96 adult trauma patients. Upon arrival at the emergency