tailieunhanh - Báo cáo y học: "Collagen-related biomarkers in severe sepsis: a big stretch"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Collagen-related biomarkers in severe sepsis: a big stretch? | Available online http content 13 3 154 Commentary Collagen-related biomarkers in severe sepsis a big stretch Gavin Morrison1 and Douglas D Fraser1 2 3 Critical Care Medicine and Paediatrics University of Western Ontario London ON N6A 5W9 Canada 2Children s Health Research Institute and Centre for Critical Illness Research London ON N6C 2V5 Canada 3Translational Research Centre London ON N6C 2V5 Canada Corresponding author Douglas D Fraser fraserd@ Published 2 June 2009 This article is online at http content 13 3 154 2009 BioMed Central Ltd Critical Care 2009 13 154 doi cc7879 See related research by Găddnăs et al. http content 13 2 R53 Abstract Biomedical scientists are aggressively investigating biomarkers of disease and injury. The rationale for identifying biomarkers during pathological states such as severe sepsis is to improve clinical prognostication and stratify therapeutic interventions for optimal recovery. An added benefit of biomarker studies is knowledge genesis on pathophysiological mechanisms critical information that provides a basis for hypothesis-driven research. Unfortunately biomarkers rarely alter our clinical approach in severe sepsis as they are often non-specific lack adequate sensitivity and or are difficult to measure and interpret accurately. Given the complexity and heterogeneity of severe sepsis and the unique genetically derived susceptibilities of individuals it is highly unlikely that one or even a handful of biomarkers will provide adequate biomedical information for clinical guidance. Thus biomarkers will ultimately alter clinical decision making only once a panel of promising biomarkers is identified maximizing sensitivity and specificity and then adequately scrutinized with quantitative scoring methods over large populations of patients. Severe sepsis is a leading cause of morbidity and mortality. Despite increased understanding of its pathophysiology our ability to .