tailieunhanh - Báo cáo y học: "The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats: is the . | Available online http content 13 2 132 Commentary The cardiac force-frequency relationship and frequency-dependent acceleration of relaxation are impaired in lipopolysaccharide-treated rats is the phospholamban-SERCA axis a therapeutic target Stephen B Heitner and Steven M Hollenberg Open Access Division of Cardiology Cooper University Hospital 3 Cooper Plaza Camden NJ 08103 USA Corresponding author Steven M Hollenberg Hollenberg-Steven@ Published 21 Apr 2009 Critical Care 2009 13 132 doi cc7752 This article is online at http content 13 2 132 2009 BioMed Central Ltd See related research by Joulin et al. http content 13 1 R1 4 Abstract Sepsis-induced myocardial dysfunction has traditionally been thought of as principally affecting systolic heart function. One of the primary reasons for this concept is that systolic dysfunction is relatively easy to conceptualize visualize and measure. With the advent of preload-independent measurements for diastolic function both measurement and conceptual difficulties are being resolved and a new realm of evidence is beginning to emerge regarding the aberrations that are found during cardiac relaxation in sepsis. A recent article in Critical Care brings this issue into sharper focus. In the previous issue of Critical Care Joulin and colleagues 1 describe an animal model of lipopolysaccharide LPS -induced impaired myocardial systolic and diastolic function. Diastole is composed of two physiological phenomena myocardial stiffness which is energy independent and active relaxation which is an ATP-requiring process 2 . Current echocardiographic techniques can help distinguish which of the two is the predominant pathway although these techniques may not always be practical in critically ill patients 3 . In some patients with sepsis a reversible component to impaired ventricular relaxation has been demonstrated 4 which would imply that the energy-requiring component of diastolic