tailieunhanh - Báo cáo y học: "Cancer immunotherapy by immunosuppression"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Cancer immunotherapy by immunosuppression. | Prehn and Prehn Theoretical Biology and Medical Modelling 2010 7 45 http content 7 1 45 THEORETICAL BIOLOGY AND MEDICAL MODELLING COMMENTARY Open Access Cancer immunotherapy by immunosuppression Richmond T Prehn Liisa M Prehn Correspondence prehn@u. Department of Pathology University of Washington 5433 South Hudson St. Seattle WA 98118 USA 2 BioMed Central Abstract We have previously suggested that the stimulatory effect of a weak immune reaction on tumor growth may be necessary for the growth of incipient tumors. In the present paper we enlarge upon and extend that idea by collecting evidence in the literature bearing upon this new hypothesis that a growing cancer whether in man or mouse is throughout its lifespan probably growing and progressing because of continued immune stimulation by a weak immune reaction. We also suggest that prolonged immunosuppression might interfere with progression and thus be an aid to therapy. While most of the considerable evidence that supports the hypothesis comes from observations of experimental mouse tumors there is suggestive evidence that human tumors may behave in much the same way and as far as we can ascertain there is no present evidence that necessarily refutes the hypothesis. Background There is in our opinion much still to be derived from the study of immunity to mouse cancers that is probably relevant to the human disease. We have previously suggested based largely upon mouse studies that incipient cancers are probably stimulated to grow by a stimulatory immune reaction. We think the evidence suggests that a new expanded hypothesis is tenable any tumor that continues to grow is probably being continuously immunologically stimulated by a low level of immunity. We will also discuss the therapeutic implications of this new hypothesis. Almost the entire literature seems currently to be predicated upon the assumption that the immune response is surveying and inhibiting cancer if indeed it does