tailieunhanh - Báo cáo y học: "Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Procalcitonin kinetics within the first days of sepsis: relationship with the appropriateness of antibiotic therapy and the outcome. | Available online http content 13 2 R38 Research Procalcitonin kinetics within the first days of sepsis relationship with the appropriateness of antibiotic therapy and the outcome Pierre Emmanuel Charles1 Claire Tinel1 Saber Barbar1 Serge Aho2 Sébastien Prin1 Jean Marc Doise1 Nils Olivier Olsson3 Bernard Blettery1 and Jean Pierre Quenot1 Service de Réanimation Médicale Hôpital Le Bocage . de Dijon 21000 Dijon France 2Service d Epidémiologie et d Hygiène Hospitalière Hôpital Le Bocage . de Dijon 21000 Dijon France 3Laboratoire d lmmunologie Hôpital Le Bocage . de Dijon 21000 Dijon France Corresponding author Pierre Emmanuel Charles Received 2 Jan 2009 Revisions requested 3 Feb 2009 Revisions received 19 Feb 2009 Accepted 16 Mar 2009 Published 16 Mar 2009 Critical Care 2009 13 R38 doi cc7751 This article is online at http content 13 2 R38 2009 Charles et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction Management of the early stage of sepsis is a critical issue. As part of it infection control including appropriate antibiotic therapy administration should be prompt. However microbiological findings if any are generally obtained late during the course of the disease. The potential interest of procalcitonin PCT as a way to assess the clinical efficacy of the empirical antibiotic therapy was addressed in the present study. Methods An observational cohort study including 180 patients with documented sepsis was conducted in our 15-bed medical intensive care unit lCU . Procalcitonin measurement was obtained daily over a 4-day period following the onset of sepsis day 1 D1 to D4 . The PCT time course was analyzed .