tailieunhanh - Báo cáo y học: "Pathological axes of wound repair: Gastrulation revisited"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Pathological axes of wound repair: Gastrulation revisited. | Aller et al. Theoretical Biology and Medical Modelling 2010 7 37 http content 7 1 37 REVIEW THEORETICAL BIOLOGY AND MEDICAL MODELLING Open Access Pathological axes of wound repair Gastrulation revisited Maria-Angeles Aller1 Jose-Ignacio Arias2 Jaime Arias1 Correspondence jariasp@ 1Surgery I Department. School of Medicine. Complutense University of Madrid. Madrid. Spain 2 BioMed Central Abstract Post-traumatic inflammation is formed by molecular and cellular complex mechanisms whose final goal seems to be injured tissue regeneration. In the skin -an exterior organ of the body- mechanical or thermal injury induces the expression of different inflammatory phenotypes that resemble similar phenotypes expressed during embryo development. Particularly molecular and cellular mechanisms involved in gastrulation return. This is a developmental phase that delineates the three embryonic germ layers ectoderm endoderm and mesoderm. Consequently in the post-natal wounded skin primitive functions related with the embryonic mesoderm . amniotic and yolk sac-derived are expressed. Neurogenesis and hematogenesis stand out among the primitive function mechanisms involved. Interestingly in these phases of the inflammatory response whose molecular and cellular mechanisms are considered as traces of the early phases of the embryonic development the mast cell a cell that is supposedly inflammatory plays a key role. The correlation that can be established between the embryonic and the inflammatory events suggests that the results obtained from the research regarding both great fields of knowledge must be interchangeable to obtain the maximum advantage. Introduction Inflammation is considered the fundamental scientific principle underlying the practice of surgery 1 . Although nowadays the main role of the inflammatory response is due to its close relationship with illness and therefore is pathological maybe the origin of these mechanisms have a different meaning

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