tailieunhanh - Báo cáo y học: "Effects of Astragaloside IV on heart failure in rats"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Effects of Astragaloside IV on heart failure in rats. | Chinese Medicine BioMed Central Research Effects of Astragaloside IV on heart failure in rats Zhuanyou Zhao 1 Weiting Wang1 Fang Wang2 Kerui Zhao3 Yingmei Han1 Weiren Xu1 and Lida Tang 1 Address 1State Key Laboratory of Pharmacokinetics and Pharmacodynamics Tianjin Institute of Pharmaceutical Research Tianjin 300193 PR China 2Department of Pharmacology Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 PR China and 3Department of Pharmacy Tianjin Medical College Tianjin 300222 PR China Email Zhuanyou Zhao - 23006858@ WeitingWang-wangweiting2000@ Fang Wang - wangfang0322@ Kerui Zhao - kerui@ Yingmei Han - Yingmei-tcmch405@ Weiren Xu - Weiren-xwrtj@ LidaTang -tangld@ Corresponding authors Open Access Published 2 April 2009 Chinese Medicine 2009 4 6 doi 1749-8546-4-6 Received 12 October 2007 Accepted 2 April 2009 This article is available from http content 4 1 6 2009 Zhao et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background Astragaloside IV ASI in Radix Astragali is believed to be the active component in treating heart failure. The present study aims to examine the effects of ASI on cardiovascular parameters in long-term heart failure in rats. Methods Using echocardiographic and haemodynamic measurements we studied the effects of ASI on congestive heart failure CHF induced by ligation of the left coronary artery in rats. Results ASI and mg kg day attenuated the decline of fractional shortening FS . The peak derivatives of the left ventricle LV pressure dp dt in ASI-treated groups .