tailieunhanh - Báo cáo y học: "Tracking tumor evolution via prostate-specific antigen: an individual post-operative study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Tracking tumor evolution via prostate-specific antigen: an individual post-operative study. | Erbudak and Erzan Theoretical Biology and Medical Modelling 2010 7 30 http content 7 1 30 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Tracking tumor evolution via prostate-specific antigen an individual post-operative study Mehmet Erbudak1 Ay e Erzan2 Correspondence erbudak@phys. laboratory for Solid State Physics ETH Zurich CH-8093 Zurich Switzerland 2 BioMed Central Abstract Background The progress of the prostate-specific antigen PSA level after radical prostatectomy is observed for a patient in order to extract information about the mode of tumor cell growth. Although PSA values are determined routinely to find the doubling time of the prostate marker to our knowledge this analysis is the first in the literature. Results The prostate tumor marker values were determined regularly after the surgery and plotted on a logarithmic scale against time. An initial rapid-growth mode changed to a slower power-law regime within two years of surgery. Our analysis associates this observation with a transition in the growth mode from unrestricted growth of dispersed cells to their clumping into macroscopic structures. Conclusions Such studies may help determine the appropriate time window for postoperative therapies in order to increase the life expectancy of the patient. Background Cancer of the prostate gland is one of the most frequently diagnosed male illnesses and may lead to death of the patient. The carcinoma is routinely detected by a straightforward blood test that measures a glycoprotein called prostate-specific antigen PSA . At an early stage of cancer growth with a localized tumor radical removal of the prostate gland has proved to be the optimum treatment. If the PSA value rises after radical prostatectomy different alternatives for treatment are currently under debate. The doubling time DT of the PSA value is accepted as a strong prognostic factor for the risk of cancer death. In a group of 379 patients almost no .