tailieunhanh - Báo cáo y học: "Commentary Arterial hypertension due to fructose ingestion: model based on intermittent osmotic fluid trapping in the small bowel"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Commentary Arterial hypertension due to fructose ingestion: model based on intermittent osmotic fluid trapping in the small bowel. | Kurbel Theoretical Biology and Medical Modelling 2010 7 27 http content 7 1 27 THEORETICAL BIOLOGY AND MEDICAL MODELLING COMMENTARY Open Access Arterial hypertension due to fructose ingestion model based on intermittent osmotic fluid trapping in the small bowel Sven Kurbel Correspondence sven@ 1 Osijek Medical Faculty Dept. of Physiology J Huttlera 4 31000 Osijek Croatia Full list of author information is available at the end of the article Abstract Based on recently reported data that fructose ingestion is linked to arterial hypertension a model of regulatory loops involving the colon role in maintenance of fluid and sodium homeostasis is proposed. In normal digestion of hyperosmolar fluids also in cases of postprandial hypotension and in patients having the dumping syndrome after gastric surgery any hyperosmolar intestinal content is diluted by water taken from circulation and being trapped in the bowel until reabsorption. High fructose corn sirup HFCS soft drinks are among common hyperosmolar drinks. Fructose is slowly absorbed through passive carrier-mediated facilitated diffusion along the entire small bowel thus preventing absorption of the trapped water for several hours. Here presented interpretation is that ingestion of hyperosmolar HFCS drinks due to a transient fluid shift into the small bowel increases renin secretion and sympathetic activity leading to rise in ADH and aldosterone secretions. Their actions spare water and sodium in the large bowel and kidneys. Alteration of colon absorption due to hormone exposure depends on cell renewal and takes days to develop so the momentary capacity of sodium absorption in the colon depends on the average aldosterone and ADH exposure during few previous days. This inertia in modulation of the colon function can make an individual that often takes HFCS drinks prone to sodium retention until a new balance is reached with an expanded ECF pool and arterial hypertension. In individuals with .