tailieunhanh - Báo cáo y học: "Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. | Chai et al. Chinese Medicine 2010 5 26 http content 5 1 26 CHINESE MEDICINE REVIEW Open Access Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines Stella Chai 1 Kenneth KW To2 Ge Lin1 Abstract Multi-drug resistance MDR of cancer cells severely limits therapeutic outcomes. A proposed mechanism for MDR involves the efflux of anti-cancer drugs from cancer cells primarily mediated by ATP-binding cassette ABC membrane transporters including P-glycoprotein. This article reviews the recent progress of using active ingredients extracts and formulae from Chinese medicine CM in circumventing ABC transporters-mediated MDR. Among the ABC transporters Pgp is the most extensively studied for its role in MDR reversal effects. While other MDR reversal mechanisms remain unclear Pgp inhibition is a criterion for further mechanistic study. More mechanistic studies are needed to fully establish the pharmacological effects of potential MDR reversing agents. Review Multi-drug resistance MDR Multi-drug resistance MDR in cancer chemotherapy refers to the ability of cancer cells to survive from treatment of a wide range of drugs 1 . In addition to the MDR induced by drugs in early exposure the MDR cancer cells may subsequently develop cross-resistance to several unexposed and structurally unrelated chemotherapeutic agents 2 . Mechanisms of MDR include decreased uptake of drugs alterations in cellular pathways and increased active efflux of drugs 3-5 Figure 1 . Overexpression of ATP-binding cassette ABC transporters is one of the most common mechanisms. ABC transporters are large membrane-bound proteins consisting of two nucleotide-binding domains NBDs and two transmembrane domains TMDs which mediate the active transport of substrate drugs out of the cell Figure 2 . Overexpression of the three major ABC transporters . P-glycoprotein Pgp multidrug-resistance-associated protein 1 MRP1 and breast cancer resistance protein BCRP ABCG2 is .