tailieunhanh - Báo cáo y học: " Research Transperineal prostate biopsy: analysis of a uniform core sampling pattern that yields data on tumor volume limits in negative biopsies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học quốc tế cung cấp cho các bạn kiến thức về ngành y đề tài: Research Transperineal prostate biopsy: analysis of a uniform core sampling pattern that yields data on tumor volume limits in negative biopsies. | Kepner and Kepner Theoretical Biology and Medical Modelling 2010 7 23 http content 7 1 23 THEORETICAL BIOLOGY AND MEDICAL MODELLING RESEARCH Open Access Transperineal prostate biopsy analysis of a uniform core sampling pattern that yields data on tumor volume limits in negative biopsies Gordon R Kepner 1 and Jeremy V Kepner2 Correspondence kepnermsp@ 1 Membrane Studies Project Minneapolis Minnesota USA Full list of author information is available at the end of the article Abstract Background Analyze an approach to distributing transperineal prostate biopsy cores that yields data on the volume of a tumor that might be present when the biopsy is negative and also increases detection efficiency. Methods Basic principles of sampling and probability theory are employed to analyze a transperineal biopsy pattern that uses evenly-spaced parallel cores in order to extract quantitative data on the volume of a small spherical tumor that could potentially be present even though the biopsy did not detect it . negative biopsy. Results This approach to distributing biopsy cores provides data for the upper limit on the volume of a small spherical tumor that might be present and the probability of smaller volumes when biopsies are negative and provides a quantitative basis for evaluating the effectiveness of different core spacing distances. Conclusions Distributing transperineal biopsy cores so they are evenly spaced provides a means to calculate the probability that a tumor of given volume could be present when the biopsy is negative and can improve detection efficiency. Background While transrectal continues to be the predominant prostate biopsy approach there is increasing interest in the transperineal approach--either initially or following a negative transrectal biopsy. Biopsy results are categorized as all or none either a tumor is found or not--which is the most likely outcome 1 . Rebiopsies bring additional cost and stress. Given the frequency .