tailieunhanh - Báo cáo y học: " Pharmacology of ginsenosides: a literature review"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Pharmacology of ginsenosides: a literature review. | Leung and Wong Chinese Medicine 2010 5 20 http content 5 1 20 CHINESE MEDICINE REVIEW Open Access Pharmacology of ginsenosides a literature review Kar Wah Leung 1 and Alice Sze-Tsai Wong2 Abstract The therapeutic potential of ginseng has been studied extensively and ginsenosides the active components of ginseng are shown to be involved in modulating multiple physiological activities. This article will review the structure systemic transformation and bioavailability of ginsenosides before illustration on how these molecules exert their functions via interactions with steroidal receptors. The multiple biological actions make ginsenosides as important resources for developing new modalities. Yet low bioavailability of ginsenoside is one of the major hurdles needs to be overcome to advance its use in clinical settings. Review Background Panax ginseng Renshen Chinese ginseng is commonly used either by itself or in combination with other medicinal ingredients as a key herb in Chinese medicine. A member of the Araliaceae family the genus name Panax was derived from the Greek word meaning all-healing first coined by the Russian botanist Carl A. Meyer. The Panax family consists of at least nine species including P ginseng Panax quinquefolium Xiyangshen American ginseng Panax notoginseng Sanqi and Panax japonicus Japanese ginseng . The worldwide sale of ginseng products has estimated to reach US 300 million in 2001 1 2 . Ginseng modulates blood pressure metabolism and immune functions 3-6 . The action mechanism of ginseng had not been known until ginsenosides were isolated in 1963 7 8 . Much effort has since been focused on evaluating the function and elucidating the molecular mechanism of each ginsenoside. Number of publications on ginseng and ginsenosides has been growing exponentially since 1975 according to the Pubmed entry. Ginsenosides are the pharmacologically active components in ginseng Ginsenosides are triterpene saponins. Most ginsenosides are .