tailieunhanh - Báo cáo y học: "Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian). | Chao and Lin Chinese Medicine 2010 5 17 http content 5 1 17 CHINESE MEDICINE REVIEW Open Access Isolation and identification of bioactive compounds in Andrographis paniculata Chuanxinlian Wen-Wan Chao and Bi-Fong Lin Abstract Andrographispaniculata Burm. f. Nees Acanthaceae is a medicinal plant used in many countries. Its major constituents are diterpenoids flavonoids and polyphenols. Among the single compounds extracted from A. paniculata andrographolide is the major one in terms of bioactive properties and abundance. Among the andrographolide analogues 14-deoxy-11 12-didehydroandrographolide is immunostimulatory anti-infective and anti-atherosclerotic neoandrographolide is anti-inflammatory anti-infective and anti-hepatotoxic 14-deoxyandrographolide is immunomodulatory and anti-atherosclerotic. Among the less abundant compounds from A. paniculata andrograpanin is both anti-inflammatory and anti-infective 14-deoxy-14 15-dehydroandrographolide is antiinflammatory isoandrographolide 3 19-isopropylideneandrographolide and 14-acetylandrographolide are tumor suppressive arabinogalactan proteins are anti-hepatotoxic. The four flavonoids from A. paniculata namely 7-0-methylwogonin apigenin onysilin and 3 4-dicaffeoylquinic acid are anti-atherosclerotic. Background Andrographis paniculata Burm. f. Nees Acanthaceae A. paniculata Chuanxinlian native to Taiwan Mainland China and India is a medicinal herb with an extremely bitter taste used to treat liver disorders bowel complaints of children colic pain common cold and upper respiratory tract infection 1-3 . The aerial part of A. paniculata is commonly used in Chinese medicine. According to Chinese medicine theory A. paniculata cools and relieves internal heat inflammation and pain and is used for detoxication 4-6 . The herb contains diterpenoids flavonoids and polyphenols as the major bioactive components 7 8 . This article reviews the constituents and pharmacological properties of A. paniculata including