tailieunhanh - Báo cáo y học: "Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Critical Care giúp cho các bạn có thêm kiến thức về ngành y học đề tài: Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa. | Chinese Medicine BioMed Central Research Cellular transport of anti-inflammatory pro-drugs originated from a herbal formulation of Zingiber cassumunar and Nigella sativa Prasan Tangyuenyongwatana1 Jariya Kowapradit2 Praneet Opanasopit2 and Wandee Gritsanapan 1 Open Access Address Department of Pharmacognosy Faculty of Pharmacy Mahidol University Bangkok 10400 Thailand and 2Department of Pharmaceutical Technology Faculty of Pharmacy Silpakorn University Nakhon Pathom 73000 Thailand Email Prasan Tangyuenyongwatana - prtang2000@ Jariya Kowapradit - neoy023@ Praneet Opanasopit - Praneet@ Wandee Gritsanapan - pywgs@ Corresponding author Published 25 September 2009 Received 7 December 2008 Accepted 25 September 2009 Chinese Medicine 2009 4 19 doi 86 1749-8546-4-19 p p This article is available from http content 4 1 19 2009 Tangyuenyongwatana et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The rhizome of Zingiber cassumunar and the seed of Nigella sativa are two ingredients in Thai traditional medicine to relieve dysmenorrhea and adjust the menstrual cycle. Mixture of these two herbs produces three esters namely E -4- 3 4-dimethoxyphenyl but-3-en-1-yl linoleate 1 E -4- 3 4-dimethoxyphenyl but-3-en-1-yl oleate 2 and E -4- 3 4-dimethoxyphenyl but-3-en-1-yl palmitate 3 . The aim of this study is to examine in vitro absorption of these esters and evaluate their transport across the membrane. Methods In vitro transport of these three esters was observed in Caco-2 cell monolayers. The ester compounds 1 2 and 3 at a concentration of10 pM were hydrolyzed by porcine liver esterase. Results All esters transported across the Caco-2 cell .